Role of CD1- and MR1-restricted T cells in Immunity and Disease

Role of CD1- and MR1-restricted T cells in Immunity and Disease
Author :
Publisher : Frontiers Media SA
Total Pages : 429
Release :
ISBN-10 : 9782889631223
ISBN-13 : 2889631222
Rating : 4/5 (23 Downloads)

Book Synopsis Role of CD1- and MR1-restricted T cells in Immunity and Disease by : Kazuya Iwabuchi

Download or read book Role of CD1- and MR1-restricted T cells in Immunity and Disease written by Kazuya Iwabuchi and published by Frontiers Media SA. This book was released on 2019-10-18 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: CD1 and MR1 are major histocompatibility complex (MHC) class I-related proteins that bind and present non-peptide antigens to subsets of T cells with specialized functions. CD1 proteins typically present lipid antigens to CD1-restricted T cells, whereas MR1 presents vitamin B-based ligands and a variety of drugs and drug-like molecules to MR1-restricted T cells. The CD1 family of antigen presenting molecules has been divided into two groups: Group 1 contains CD1a, CD1b and CD1c, and Group 2 contains CD1d. Additionally, CD1e is expressed intracellularly and is involved in the loading of lipid antigens onto Group 1 CD1 proteins. Humans express both Groups 1 and 2 CD1 proteins, whereas mice only express CD1d. Group 1 CD1 proteins present lipid antigens to T cells that generally express diverse T cell receptors (TCRs) and exhibit adaptive-like functions, whereas CD1d presents lipid antigens to subsets of T cells that express either diverse or highly restricted TCRs and exhibit innate-like functions. CD1d-restricted T cells are called natural killer T (NKT) cells, which includes Type I or invariant NKT (iNKT) cells expressing semi-invariant TCRs, and Type II NKT cells expressing more diverse TCRs. CD1-restricted T cells have been implicated in a wide variety of diseases, including cancer, infections, and autoimmune, inflammatory and metabolic diseases. Additionally, NKT cells have been targeted for immunotherapy of disease with ligands such as α-galactosylceramide for iNKT cells, or sulfatide for Type II NKT cells. Like iNKT cells, MR1-restricted T cells express semi-invariant TCRs and display innate-like functions. MR1-restricted T cells, also called mucosal-associated invariant T (MAIT) cells, have been implicated in immune responses against a variety of pathogens such as Mycobacterium tuberculosis, Pseudomonas aeruginosa, Helicobacter pylori, hepatitis C virus and influenza virus. Moreover, these cells contribute to autoimmune and inflammatory diseases, including colitis, rheumatoid arthritis, psoriasis, lupus, and diabetes.


Role of CD1- and MR1-restricted T cells in Immunity and Disease Related Books

Role of CD1- and MR1-restricted T cells in Immunity and Disease
Language: en
Pages: 429
Authors: Kazuya Iwabuchi
Categories:
Type: BOOK - Published: 2019-10-18 - Publisher: Frontiers Media SA

DOWNLOAD EBOOK

CD1 and MR1 are major histocompatibility complex (MHC) class I-related proteins that bind and present non-peptide antigens to subsets of T cells with specialize
CD1- and MR1-restricted T Cells in Antimicrobial Immunity
Language: en
Pages: 191
Authors: S.M. Mansour Haeryfar
Categories: Cytology
Type: BOOK - Published: 2016-01-21 - Publisher: Frontiers Media SA

DOWNLOAD EBOOK

Cell-mediated immunity to extracellular and intracellular microbes has been traditionally linked to CD4+ and CD8+ T cells that recognize pathogen-derived peptid
T Cell Activation by CD1 and Lipid Antigens
Language: en
Pages: 346
Authors: Branch D. Moody
Categories: Medical
Type: BOOK - Published: 2007-05-10 - Publisher: Springer Science & Business Media

DOWNLOAD EBOOK

There is increasing evidence that the CD1 system has been conserved throughout mammalian evolution and is capable of presenting structurally diverse diacyglycer
Regenerative Nephrology
Language: en
Pages: 528
Authors: Michael S. Goligorsky
Categories: Science
Type: BOOK - Published: 2021-06-12 - Publisher: Academic Press

DOWNLOAD EBOOK

Since the publication of the first edition of this book in 2010, an explosion of spectacular discoveries in the field of regeneration has compelled the current
Innate Immune Cell Determinants of T Cell Immunity: From Basic Mechanisms to Clinical Implications
Language: en
Pages: 145
Authors: Elisabetta Padovan
Categories: Immunologic diseases. Allergy
Type: BOOK - Published: 2016-07-14 - Publisher: Frontiers Media SA

DOWNLOAD EBOOK

Long-lasting T cell immunity is delivered by an array of individual T lymphocytes expressing clonally distributed and highly specific antigen receptors recogniz